Fifth Disease Causes, Symptoms, Diagnosis Fifth disease is a mild illness caused by a virus known as human parvovirus B19. The medical name for fifth disease is erythema infectiosum (EI). It is seen primarily in school-aged children between 5 and 14 years of age during the spring and winter.
Fifth Disease Fact Sheet Fifth disease is a viral infection which often affects red blood cells. It is caused by a human parvovirus (B19) . For many years, fifth disease was viewed as an unimportant rash illness of children.
Fifth Disease in the Child Care Setting Fifth disease, also called erythema infectiosum or "slapped cheek disease," is an infection caused by parvovirus B19. Outbreaks most often occur in winter and spring, but a person may become ill with fifth disease at any time of the year. Symptoms begin with a mild fever and complaints of tiredness. After a few days, the cheeks take on a flushed appearance that looks like the face has been slapped. There may also be a lacy rash on the trunk, arms, and legs. Not all infected persons develop a rash.